Tiny Intensifiers: Nanoparticles Worsen Lung Effects of Bacterial Endotoxin
نویسندگان
چکیده
منابع مشابه
Effects of Airway Exposure to Nanoparticles on Lung Inflammation Induced by Bacterial Endotoxin in Mice
BACKGROUND Although adverse health effects of particulate matter with a diameter of < 100 nm (nanoparticles) have been proposed, molecular and/or experimental evidence for their facilitation of lung inflammation in vivo is not fully defined. OBJECTIVE In the present study we investigated the effects of nanoparticles on lung inflammation related to bacterial endotoxin [lipopolysaccharide (LPS)...
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Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet fa...
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Bacterial endotoxin (lipopolysaccharide) has a variety of biological and immunological activities. Endotoxin-induced physiological changes in several organs might modify the pharmacokinetic behavior, including the biliary and urinary excretions and hepatic metabolism, of various drugs. We have conducted a series of studies as part of a program for the development of guidelines for the safe use ...
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PURPOSE This study evaluates the effects of the gold nanoparticle in endotoxin-induced uveitis in rats. METHODS Adult male Wistar rats were divided into five groups: saline + saline, lipopolysaccharide (LPS) + saline, LPS + prednisolone, LPS + gold salt (GS) and LPS + gold nanoparticle (GNP). Two hours after LPS administration, prednisolone acetate 1%, GS, and GNP were topically applied to bo...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2006
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.114-a545b